Scientific Editing report - illustration
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چکیده
A prolonged decrease in serum sodium concentration can cause chronic hyponatremia, a condition that is frequent among the elderly and that, in spite of a reputation for being asymptomatic, is increasingly recognized as being potentially harmful. This paper proposes the inhibition of 11hydroxysteroid dehydrogenase type 2 (11-HSD2) as a novel means of treating chronic hyponatremia. They identify DE2300c5 as a potent and specific inhibitor of 11-HSD2, and describe a marked increase in intracellular sodium in renal cortical cells treated with this agent.
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